METHOD FOR CORRECTION OF ENDOTHELIAL DYSFUNCTION BY COMBINATION OF AMLODIPINE AND L-ARGININE IN L-NAME-INDUCED DEFICIENCY OF NITROGEN OXIDE

摘要

FIELD: medicine, experimental cardiopharmacology.;SUBSTANCE: dysfunction is modeled in experiment by every day intraperitoneal administration to rats of L-arginine nitromethyl ester for 7 days in the dose 25 mg/kg. On this background amlodipine is administrated into stomach in the dose 0.5 mg/kg, and L-arginine is administrated by intraperitoneal route in the dose 200 mg/kg once per 24 h. Method provides effective correction under the definite modeling conditions.;EFFECT: improved method of dysfunction correction.;2 tbl, 1 ex