Use of gene alterations in the human gene chk1 which, for the check point kinase 1 codes

摘要

The present invention relates to the use of gene alterations in the human gene chk1 (chek1) which, for the check point kinase 1, for predicting the course of cancer diseases and for predicting the response to pharmacological or not - pharmacological therapeutic measures for the treatment of cancerous diseases and for predicting undesirable side effects. Furthermore, the invention relates to the provision of individual gene variants, with the aid of which further for the above-mentioned purposes, gene alterations which can be used, can be detected, and can be validated. Such gene alterations can reside in that, in the promoter of chk1 at position - 1143 a degree of substitution vn guanine to thymine is present, at position - 1400 cytosine to thymine, at position - 1453 to a substitution of thymine, cytosine is present or at position - 1454 an insertion of a cytosine is present. The gene alterations can be individually or collectively in arbitrary combinations by means of the person skilled in the art is familiar to the method can be detected.