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assays for monitoring of cancer patients based on the levels of analytenkomponenten of the plasminogen activator system in samples of body fluids
assays for monitoring of cancer patients based on the levels of analytenkomponenten of the plasminogen activator system in samples of body fluids
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机译:体液样本中的纤溶酶原激活剂系统的分析物桥联蛋白水平检测癌症患者的血浆分析
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摘要
The present invention describes clinically and medically important methods of examining, screening over time, and monitoring the outcome of a cancer patient who is undergoing treatment or therapy for his or her disease. More specifically, the invention provides a method of monitoring the progression of disease, or the effectiveness of cancer treatment, in a cancer patient by measuring the levels of one or more analytes of the plasminogen activator (uPA) system, namely, uPA, PAI-1 and the complex of uPA:PAI-1, in a sample taken from the cancer patient, preferably, before treatment, at the start of treatment, and at various time intervals during treatment. As a result of performing the method, an increase or elevation in the levels of one or more of the PA system analytes in the cancer patient compared with the levels one or more of the respective PA system analytes in normal control individuals serves as an indicator of cancer advancement or progression and/or a lack of treatment effectiveness for the patient.
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