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Phages - display - selection system for correctly folded proteins
Phages - display - selection system for correctly folded proteins
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机译:噬菌体-展示-正确折叠蛋白质的选择系统
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摘要
The present invention concerns a method for the selection of a virus comprising the steps of: (a) providing a virus encoding and displaying a fusion polypeptide, said fusion polypeptide comprising a heterologous polypeptide inserted into the sequence of a viral coat protein polypeptide, wherein said virus comprises a cleavable site located within a displayed polypeptide; (b) exposing the virus to a cleaving agent; (c) propagating the virus comprising intact fusion protein.
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