Metabotropic glutamate receptor (mGluR4) modulators having 5- or 6-membered N-heteroaryl ring substituted by both N-cyclylamino amp; 5-membered N-heteroaryl ring

摘要

Compounds of formula (I): ```wherein: DL TSIZE=18 COMPACT=COMPACT DTX1, X2, X3 and X4DDare C, N, O, S or C=C, such that the ring is a 5- or 6-membered heteroaryl ring which is further substituted by 1 to 3 radicals Am; DTAmDDis H, a substituent as defined in the specification, or any two radicals Am taken together may form an optionally substituted 3- to 10-membered carbocyclic or heterocyclic ring; DTY1, Y2, Y3 and Y4DDare C or N, such that the ring is a 5-membered heteroaryl ring which is further substituted by 1 to 3 radicals Bm; DTBmDDis H, a substituent as defined in the specification, or any two radicals Bm taken together may form an optionally substituted 3- to 10-membered carbocyclic or heterocyclic ring; DTM1DDis an optionally substituted 3- to 10-membered ring selected from aryl, heteroaryl, heterocyclic and cycloalkyl; DTM2DDis H or a substituent as defined in the specification; DTM3DDis H or ```an optionally substituted radical selected from: ```-C0-6-alkyl-CO-R11, ```-C2-6-alkyl-S(O)R11, ```-C0-6-alkyl-CO-NR11R12, and ```-C0-6-alkyl-SO2-R11, DTR11 and R12DDand H or an optionally substituted radical selected from: ```-C1-6-alkylhalo, ```-C1-6-alkyl, ```-C1-6-alkylcyano, ```-C3-7-cycloalkyl ```-C4-10-alkyl-cycloalkyl, heteroaryl, ```-C1-6-alkylheteroaryl, aryl, ```-C1-6-alkylaryl, and heterocycle; /DL and stereoisomers, acid/base addition salts, and N-oxides thereof are modulators of metabotropic glutamate receptors - subtype 4 (mGluR4) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluRA4 receptors. Such compounds may also be used to prepare a tracer for imaging an metabotropic glutamate receptor. They may also be used as a taste agent, a flavour (or flavour enhancing) agent, or a food or beverage additive.