COMBINATION FOR TREATMENT OF DISEASE INVOLVING CELL PROLIFERATION, MIGRATION OR APOPTOSIS OF MYELOMA CELL OR ANGIOGENESIS

摘要

PPROBLEM TO BE SOLVED: To provide a pharmaceutical combination for the treatment of diseases which involves cell proliferation, migration or apoptosis of myeloma cells, or angiogenesis. PSOLUTION: The pharmaceutical combination includes following two kinds of components: (i) an antagonist of at least one receptor selected from VEGFR 1 to 3, PDGFR and , FGFR1, 2 and 3, EGFR, HER2, IGF1R, HGFR or c-Kit, (this is further an antagonist of a src tyrosine kinase family member); and (ii) at least a further chemotherapeutic or naturally occurring, semi-synthetic or synthetic therapeutic agent. PCOPYRIGHT: (C)2010,JPO&INPIT