HUMAN MONOCLONAL ANTIBODY TO Fcalpha RECEPTOR (CD89)

摘要

PPROBLEM TO BE SOLVED: To provide a human monoclonal antibody specifically binding to Fc receptor (CD89) including a monoclonal antibody specifically reacting with the Fc receptor for IgA of human effector cells. PSOLUTION: An isolated monoclonal antibody comprising specific sequences of a heavy chain variable region and a light chain variable region and specifically binding to human Fc receptor (CD89), or an antigen-binding fragment thereof is provided. The antibody is a bifunctional antibody or a heteroantibody and is useful for targeting human effector cells (e.g. macrophage) against a target cell (e.g. a cancer cell, an infectious material and the like). PCOPYRIGHT: (C)2010,JPO&INPIT