USE OF OXY-INDOLE DERIVATIVE IN TREATMENT OF DEMENTIA-ASSOCIATED DISEASE, ALZHEIMER DISEASE AND GLYCOGEN SYNTHASE KINASE-3-ASSOCIATED SYMPTOM

摘要

PPROBLEM TO BE SOLVED: To provide a new active compound effective for the prevention and/or treatment of dementia-associated diseases, Alzheimer diseases, and glycogen synthase kinase-3-associated symptoms and a method for producing the same. PSOLUTION: This free base or its pharmaceutically acceptable salt of an oxy-indole derivative expressed by formula I [wherein, RSP1/SPis H or a 1-3C alkyl; RSP2/SPis hydroxy, a halogeno, trifluoromethyl, cyano, amino, nitro, carboxy, a 1-3C alkyl, a 1-3C alkoxy, a 1-3C alkanoyloxy, a 2-4C alkanoyl, a 1-4C alkanoylamino or the like; and RSP3/SPis hydroxy, a halogeno, nitro, trifluoromethyl, a 1-3C alkyl, cyano, amino or the like] is provided. PCOPYRIGHT: (C)2010,JPO&INPIT