Production method of olmesartan medoxomil and trityl olmesartan medoxomil

摘要

A process for the preparation of trityl olmesartan medoxomil, alkali metal carbonates, alkali metal hydroxides, alkali metal alkoxides, and in the presence of a base selected from the group consisting of tertiary amines as well as (a) a polar aprotic solvent, 4-(1-hydroxy-1-methylethyl)-2-propyl - condensation of biphenyl and trityl bromide and imidazole-5-carboxylic acid alkyl ester, a step of obtaining a compound of formula V, (b) formula (V) The reaction of the process of de-esterification using a base compound, and the product (c) the step (b) of formula (IV) of 4-halomethyl-5-methyl-2-dioxolen method comprising (wherein, X is a halogen selected from I, or Br or Cl or F), and the step of obtaining the trityl olmesartan medoxomil is allowed to. Trityl olmesartan medoxomil, the olmesartan medoxomil to be deprotected. [Formula 1] [2] of None [Selection Figure]