Furan ring and ring fused 1,2-dioxetane derivative, measurement reagent and measurement method using the derivative

摘要

PROBLEM TO BE SOLVED: To provide a new 1,2-dioxetane derivative having high thermal stability and high light-emitting efficiency, visually recognizable owing to its reddish color, easy to handle and useful in the field of clinical test, etc. ;SOLUTION: This compound is a 1,2-dioxetane derivative expressed by formula I [R¹ to R⁵ are each H, an alkyl, an aryl or the like; Ar is a group of formula II (R⁶ is hydroxyl or the like; R⁷ is H, an alkyl, an aryl or the like; V is O or S) or the like], e.g. the compound of formula III. The compound of formula I can be produced e.g. by reacting a dihydrofuran derivative of formula IV (R⁶¹ is an alkoxy or the like; (R⁶¹) Ar is a group of formula V or the like) having an aryl group substituted with R⁶¹, a compound obtained by the deprotection of the derivative of formula IV or a compound produced by introducing a silyloxy group or a phosphate group into the deprotected derivative of formula IV with singlet oxygen. The compound of formula I may be used in combination with other compound having light-emitting characteristics.;COPYRIGHT: (C)1999,JPO