A Ring-Expansion Methodology Involving Multicomponent Reactions: Highly Efficient Access to Polysubstituted Furan-Fused 1,4-Thiazepine Derivatives

摘要

1,4-Thiazepine fragments are present in a wide range of natural and synthetic biologically active agents.[1] Among these, analogues of 1,4-thiazepines fused with aryl and heteroaryl groups represent an important class of compounds with interesting pharmacological properties,[2] such as antiarrhythmic, antispasmodic, angiogenic, and central nervous system activity, and are therefore promising synthetic targets for exploring novel physiologically active agents.