PROBLEM TO BE SOLVED: To rigidly joint an edge portion of an instrument penal reinforcement 11 at a vehicle body frame, facilitate its mounting at an execution surface, and absorb a shape error in a vehicle width direction in the instrument panel reinforcement structure.;SOLUTION: This instrument panel reinforcement structure is constituted of the instrument penal reinforcement 11, a mounting bracket 12 made of aluminum extrusion material fixed at both edge portions, and a bracket 13 on a vehicle body side jointed to the mounting bracket 12 with bolts. The extrusion direction of the mounting bracket 12 is the vehicle width direction, and the bracket is constituted of a pair of vertical wall type flanges 15, 16 which are weld-jointed with flanges 11a, 11b on the front and rear of the instrument penal reinforcement 11 and a wall type rib 17 which joints the flanges. The bracket 13 on the vehicle body side is constituted of a mounting portion 21 and a flange portion 22 in a step condition, and extension portions 15a, 16a of the mounting bracket are jointed to the vertical wall type flanges 22a, 22b of the flange portion 22 with bolts.;COPYRIGHT: (C)2006,JPO&NCIPI
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机译: 6.一种化合物,其包含具有根据20的EP-B1-2563920(SEQ ID NO:80)的具有由20个连接的核苷组成的核碱基序列的修饰的寡核苷酸,其中所述修饰的寡核苷酸包含:由十个连接的脱氧核苷组成的缺口片段;和由五个连接的核苷组成的5'翼区段; 3'翼段由五个连接的核苷组成;其中所述间隙片段位于5'侧翼片段和3'侧翼片段之间,其中每个侧翼片段的每个核苷包含2'-O-甲氧基乙基糖;其中修饰的寡核苷酸的每个胞嘧啶是5-甲基胞嘧啶,并且其中修饰的寡核苷酸的每个核苷间键是硫代磷酸酯键;特别是inotersen;及其衍生物,例如由EP-B1-2563920保护的其盐,包括钠盐。
机译: 6.一种化合物,其包含具有根据20的EP-B1-2563920(SEQ ID NO:80)的具有由20个连接的核苷组成的核碱基序列的修饰的寡核苷酸,其中所述修饰的寡核苷酸包含:由十个连接的脱氧核苷组成的缺口片段;和由五个连接的核苷组成的5'翼区段; 3'翼段由五个连接的核苷组成;其中所述间隙片段位于5'侧翼片段和3'侧翼片段之间,其中每个侧翼片段的每个核苷包含2'-O-甲氧基乙基糖;其中修饰的寡核苷酸的每个胞嘧啶是5-甲基胞嘧啶,并且其中修饰的寡核苷酸的每个核苷间键是硫代磷酸酯键;特别是inotersen;及其衍生物,例如由EP-B1-2563920保护的其盐,包括钠盐。