Double-stranded nucleic acid molecule targeting human papillomavirus type 16 gene and pharmaceutical comprising the same

摘要

The object of the present invention is to provide double-stranded nucleic acid molecules such as siRNA having high inhibitory activity and high specificity for the expression of human papillomavirus (HPV) type 16 oncogene, and diseases caused by HPV type 16 infection (for example, The object is to provide a medicament or the like suitable for treatment or prevention of cervical cancer. That is, the present invention relates to a double-stranded nucleic acid molecule targeting a specific sequence in HPV16 type E6 and E7 oncogenes and having high inhibitory activity and high specificity for expression of the gene; The present invention relates to DNA, vectors, and medicines including nucleic acid molecules.