Anti-prion active compound, anti-prion activator and method for inhibiting abnormal prion protein production

摘要

An object of the present invention is to provide an anti-prion active compound having an excellent effect of suppressing an increase in abnormal prion protein. Furthermore, an anti-prion active agent and a method for inhibiting the production of abnormal prion protein using the anti-prion active compound are provided. The anti-prion active compound of the present invention is a pyrazolone derivative represented by the following general formula (1). In the formula, R1 represents an aryl group which may have a substituent or an alkyl group (including a cycloalkyl group) which may have a substituent, R2 represents hydrogen, an aryl group which may have a substituent, A nitrogen-containing heterocyclic functional group which may have a substituent, an alkyl group (including a cycloalkyl group) or an acyl group which may have a substituent, and R3 an aryl group which may have a substituent , An optionally substituted alkyl group (including a cycloalkyl group), RCONH-, RNHCO-, ROCONH- or RNHCONH- (wherein R represents an aryl group or an alkyl group (including a cycloalkyl group)) Show). [Selection figure] None