Fast methylation method, PET tracer preparation kit, and PET tracer manufacturing method

摘要

[PROBLEMS] To provide an aromatic compound or an alkenyl compound labeled with a methyl group or a fluoromethyl group under a mild condition using an organoboron compound which is not very toxic as a substrate, and capable of obtaining an aromatic compound quickly and with high yield. Provided are a method for rapid methylation of a compound or an alkenyl compound, a kit for preparing a PET tracer used therein, and a method for producing a PET tracer using the same. An organoboron compound in which methyl iodide or X—CH 2 F (where X is a functional group that can be easily removed as an anion) and an aromatic ring or alkenyl group are bonded to boron in an aprotic polar solvent. Are cross-coupled in the presence of a palladium (0) complex, a phosphine ligand and a base.