METHOD FOR PRODUCING PRECURSORS FOR L-3,4-DIHYDROXY-6- 18F FLUOROPHENYL ALAINE AND 2- 18F FLUORO-L-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES THEREOF, PRECURSOR, AND METHOD FOR PRODUCING L-3, 4DIHYDROXY-6- 18F FLUOROPHENYLALANINE AND 2- 18F FLUORO-L-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES FROM THE PRECURSOR

摘要

Disclosed is a method for producing precursors for L-3,4-dihydroxy-6-[¹⁸F]fluorophenylalanine and 2-[¹⁸F]fluoro-L-tyrosine and the α-methylated derivatives thereof, the precursor, and to a method for producing L-3,4-dihydroxy-6-[¹⁸F]fluorophenylalanine and 2-[¹⁸F]fluoro-L-tyrosine and the α-methylated derivatives thereof from the precursor. A compound of formula (3) is provided which enables automated synthesis of L-3,4-dihydroxy-6-[¹⁸F]fluorophenylalanine and 2-[¹⁸F]fluoro-L-tyrosine. The enantiomeric purity of the product is ≧98%.