METHOD FOR PRODUCING PRECURSORS FOR L-2- 18F FLUOROPHENYLALANINE AND 6- 18F FLUORO-L--META-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES THEREOF, PRECURSOR, AND METHOD FOR PRODUCING L-2- 18F FLUOROPHENYLALANINE AND 6- 18F FLUORO-L-META-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES FROM THE PRECURSOR

摘要

Disclosed is a method for producing precursors for 2-[¹⁸F]fluorophenylalanine and 6-[¹⁸F]fluoro-L-meta-tyrosine and the α-methylated derivatives thereof, to the precursor, and to a method for producing 2-[¹⁸F]fluorophenylalanine and 6-[¹⁸F]fluoro-L-meta-tyrosine and the α-methylated derivatives thereof from particular precursor. A compound of formula (3) is provided which enables an automated synthesis of L-3,4-dihydroxy-6-[¹⁸F]fluorophenylalanine and 6-[¹⁸F]fluoro-L-meta-tyrosine. The enantiomeric purity of the product is ≧98%.