COMBINATION OF VITAMIN K AND VITAMIN K ANTAGONIST SUCH AS R-ISOMER OF WARFARIN, PHENPROCOUMON OR R-ISOMER OF PHENPROCOUMON AS ANTICOAGULANT THERAPY

摘要

Medications which are derived by combining one or more doses of the agonist, vitamin K, with doses of one or more selected vitamin K antagonists such as the R-isomer of warfarin, the R-isomer of phenprocoumon, or the racemic phenprocoumon are useful in anticoagulant therapy. These products are designed to minimize or circumvent the detrimental impact of newly identified genetic-based variables that currently significantly complicate the therapeutic response of individual patients to anticoagulation therapy.