1-2-AMINO-3-(SUBSTITUTED ALKYL)-3H-BENZIMIDAZOLYLMETHYL-3-SUBSTITUTED-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONES AND STRUCTURAL ANALOGS

摘要

Inhibitors of RSV replication of formula (I) which can be represented by formula (I); ;the salts and stereochemically isomeric forms thereof, wherein R is a radical of formula; ;Q is hydrogen or C_1-6alkyl optionally substituted with a heterocycle or Q is C_1-6alkyl substituted with both a radical —OR⁴ and a heterocycle; Alk is C_1-6alkanediyl;X is O or S; -a¹=a²-a³=a⁴- is —N═CH—CH═CH—, —CH═N—CH═CH—, —CH═CH—N═CH— or —CH═CH—CH═N—; R¹ is Ar or a heterocycle;R² is hydrogen, C_1-6alkyl, substituted C_1-6alkyl, C_3-7cycloalkyl; R³ is hydrogen, C_1-6alkyl, cyano, aminocarbonyl, polyhaloC_1-6alkyl, C_2-6alkenyl or C_2-6alkynyl;R⁴ is hydrogen or C_1-6alkyl; Ar is phenyl or substituted phenyl; Het is a heterocycle; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I).