METHOD FOR ENHANCING COGNITION OR INHIBITING COGNITIVE DECLINE

摘要

A method for enhancing cognition or inhibiting cognitive decline in a subject comprises selecting a Ca²⁺ channel blocker that is effective, when administered intravenously to an animal in a nontoxic amount, to increase NF-κB expression in the brain of the animal; and administering the selected Ca²⁺ channel blocker to the subject, via a systemic route that affords an adequate therapeutic window for cognition-enhancing or cognitive decline-inhibiting effectiveness of the selected Ca²⁺ channel blocker, in an amount within the therapeutic window. The selected Ca²⁺ channel blocker can be, for example, tiapamil or a pharmaceutically acceptable salt or prodrug thereof.