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Thiophene derivatives for up-regulating HLA-DM activity
Thiophene derivatives for up-regulating HLA-DM activity
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机译:噻吩衍生物可上调HLA-DM活性
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摘要
Compounds of formula (I), compositions, methods and kits are provided. The compounds and compositions may be particularly useful for modulating immunological responses. Formula (I) wherein, R1 is alkyl, aryl, or heterocyclyl; R2 is H, alkyl, aryl, heterocyclyl, OR3 or N(R3)2, R3 is H, alkyl, aryl, or heterocyclyl; R4 is H, CN, halogen, CF3, CO2R3, or C(O)N(R3)2; X is S, SO2, O, or NR3; and Y is S, O, or NR3.; 展开▼
机译:提供了式(I)的化合物,组合物,方法和试剂盒。该化合物和组合物对于调节免疫应答可能是特别有用的。式(I),其中,R Sub 1是烷基,芳基或杂环基; R 2 Sub>是H,烷基,芳基,杂环基,OR 3 Sub>或N(R 3 Sub>) 2 Sub>,R 3 Sub>是H,烷基,芳基或杂环基; R 4 Sub>是H,CN,卤素,CF 3 Sub>,CO 2 Sub> R 3 Sub>或C(O) N(R 3 Sub>) 2 Sub>; X是S,SO 2 Sub>,O或NR 3 Sub>; Y是S,O或NR 3 Sub>。 <图像文件=“ US20100143404A1-20100610-C00001.GIF” he =“ 22.94mm” imgContent =“ chem” imgFormat =“ GIF” wi =“ 55.63mm” /> 化学>
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