The Reaction of 2-Aminocyclohexeno[b]thiophene Derivatives with Ethoxycarbonyl isothiocyanate:Synthesis of Fused Thiophene Derivatives with Antibacterial and Antifungal Activities

摘要

The reaction of 2-amino-tetrahydrobenzo[b]thiophene derivatives 1a-d with ethoxycarbonyl isothiocyanate(2)gave the tetrahydrobenzo[b]thiophen-2-thiourea derivatives 3a-d.The latter products underwent ready cyclizations when heated in sodium ethoxide solution to give annulated derivatives 4a-d.Compounds 3a-d also underwent hetero-cyclizations to give fused thiophene derivatives with antibacterial and antifungal activities.