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THERMALLY-TARGETED DELIVERY OF MEDICAMENTS INCLUDING DOXORUBICIN
THERMALLY-TARGETED DELIVERY OF MEDICAMENTS INCLUDING DOXORUBICIN
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机译:包括阿霉素在内的药物的靶向治疗
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摘要
Elastin-like polypeptide (ELP) serves as a vector for thermally-targeted delivery of therapeutics, including cytotoxic chemotherapeutic drugs such as doxorubicin. Examples of an ELP-based delivery vehicle can comprise: (1) a cell penetrating peptide, such as a Tat protein, (2) ELP, and (3) the lysosomally degradable glycylphenylalanylleucylglycine (GFLG) spacer and a cysteine residue conjugated to therapeutic such as doxorubicin, or a analog thereof.
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