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THERMALLY-TARGETED DELIVERY OF MEDICAMENTS, INCLUDING DOXORUBICIN
THERMALLY-TARGETED DELIVERY OF MEDICAMENTS, INCLUDING DOXORUBICIN
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机译:药物(包括阿霉素)的靶向治疗
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摘要
Elastin-like polypeptide (ELP) serves as a vector for thermally-targeted delivery of therapeutics, including cytotoxic chemotherapeutic drugs such as doxorubicin. Examples of an ELP-based delivery vehicle can comprise: (1) a cell penetrating peptide, such as a Tat peptide, (2) ELP, and (3) the lysosomally degradable glycylphenylalanylleucylglycine (GFLG) (SEQ ID NO: 3) spacer and a cysteine residue (SEQ ID NO: 4) conjugated to therapeutic such as doxorubicin, or an analog thereof.
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机译:弹性蛋白样多肽(ELP)用作热靶向递送治疗剂的载体,包括细胞毒性化疗药物(如阿霉素)。基于ELP的递送载体的实例可包含:(1)细胞穿透肽,例如Tat肽,(2)ELP,和(3)溶酶体可降解的糖基苯基丙氨酰亮氨基甘氨酸(GFLG)(SEQ ID NO:3)间隔子和与治疗剂例如阿霉素结合的半胱氨酸残基(SEQ ID NO:4)或其类似物。
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