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Novel Cultured Silkworm Cells Capable of Highly Efficient Baculovirus Production and Protein Production
Novel Cultured Silkworm Cells Capable of Highly Efficient Baculovirus Production and Protein Production
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机译:新型高效培养杆状病毒和蛋白质生产能力的家蚕细胞
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摘要
Known cell lines derived from silkworm exhibit low propagation efficiency of BmNPV. Accordingly, systems using known culture cell lines derived from silkworms take a long time to establish recombinant viruses, and are not suitable for preparation of virus solutions with high titers. The present invention provides a cell line Bme21 (FERM P-20852) that is derived from a silkworm embryo and is highly susceptible to BmNPV or its variant having the same biological characteristics. The present invention also provides a method of producing a recombinant virus, a method of producing a recombinant protein, a method of increasing efficiency of recombinant virus production, and a method of increasing efficiency of recombinant protein production, using the cell line Bme21 or its variant.
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