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Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery
Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery
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机译:通过表达靶向基因传递指导COX-2过表达癌细胞的凋亡
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摘要
The present invention provides methods and constructs for selectively expressing an Apoptosis-Inducing Gene (AIG) in a population of cells that overexpress cyclooxygenase-2 (COX-2) to induce apoptosis in the cell. To achieve this goal a chimeric gene construct is used that comprises a cyclooxygenase-2 promoter (COX-2 promoter) that is operably linked to at least one AIG such that the COX-2 promoter is activated in cells that overexpress COX-2, thereby resulting in transcription and translation of the AIG, which in turn activates apoptosis in the cell. Thus, apoptosis is selectively induced in only those cells capable of overexpressing COX-2.
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