Derivatives of imidazo 1,2-a pyridine positive allosteric modulators of mGluR2 Receptors, Pharmaceutical compositions containing them and Uses Thereof in the treatment of Neurological and Psychiatric Disorders.

摘要

Claim 1: a compound having the formula (1) or one of its forms estereoquu00edmicamente isomeric where R1 is alkyl, cycloalkyl C1 - C3 - 6 6 trifluoromethyl; replaced with trifluoromethyl c1-3 alkyl, cycloalkyl 2,2,2-trifluoroethoxy, C3 - 7 phenyl or substituted phenyl alkyl C1 - 3, 3 - C1 - Oxy alkyl, cyano, haloTrifluoromethyl or trifluoromethoxy substituted phenyl; with 1 or 2; phenyl substituents selected from the group consisting of c1-3 alkyl, alkyl C1 - 3 - Oxy, cyano, trifluoromethyl and Halo, or trifluoromethoxy; 4 - tetrahidropiranilo; R2 is Halo, cyano, trifluoromethyl, c1-3 alkyl or ciclopropilo; R3 is A radical of formula (a) or (b) or (c) or (d); R4 is Hydrogen; hidroxicicloalquilo C3 - 6Pyridinyl substituted pyridinyl; with one or two c1-3 alkyl groups, pirimidinilo; pirimidinilo replaced with one or two alkyl groups C1 3 phenyl substituted with 1 or 2; phenyl substituents selected from the group consisting of c1-3 alkyl, Halo, hidroxialquilo c1-3, mono - or polihaloalquilo C1 - 3, cyano, amino, hydroxyl, carboxyl, c1-3 alkyl - oxialquilo c1-3, c1-3 alkyl - oxiMono - or polihalo c1-3 alkyl - Oxy, c1-3 alkyl carbonyl, mono - and di (c1-3 alkyl or phenyl) amino and morfolinilo; two vicinal substituents which, taken together, form a Bivalent radical formula N = CH - (e) - NH, - ch = CH - NH - (f), or - or - CH2 - ch2-nh - (g); R5 is Hydrogen, fluoro, hydroxyl, Hydro Xialquilo c1-3, hidroxialquil C1 - 3 - Oxy, fluoroalquilo c1-3, fluoroalquil C1 - 3 - oxiMorfolinilo or cyano; X is c or n in which case R5 represents a pair of electrons in the N - X; R4 or R5 represents a radical of formula (H) or (i) or (j) n is 0 OR 1; Q is 1 or 2; R6 c1-3 alkyl, cycloalkyl hidroxialquilo C2 - C3 - 6, 6 - 4 pp. ISBN; cicloalquil c1-3 alkyl or phenyl, phenyl, or pirid pyridinyl; Quot replaced with one or two substituents selected from the group consisting of haloC1-3 alkyl, alkoxy hidroxialquilo C1 C1 - 3 - 3 - trifluoromethyl and (CH2) CO2H m, where M = 0, 1, or 2, or cyclical R6 is a radical of formula (k) where R8 is Hydrogen, alkyl c1-3, c1-3 alkyl - oxi hidroxialquilo c1-3; p is 1 or 2; Z is o or CR9 CH2 (OH), where R0 is Hydrogen or c1-3 alkyl R8 and R9 form; or a radical - CH2 - CH2 - R7 is Hydrogen;Halo or trifluoromethyl, and it is a Covalent Bond, or NH, S, so, SO2, C (OH) (CH3), - CH2 -, - or - CH2 -, CHF or CF2; or R6 - and is morfolinilo, pirrolidinilo or piperidinilo optionally substituted with hydroxyl or hidroxialquilo c1-3; and it is o or NH; or a pharmaceutically acceptable Salt or its solvates.