Derivatives - 1,2,4 triazolo 4,3-a pyridine positive allosteric modulators of mGluR2 Receptors, Pharmaceutical compositions containing them and their use in the treatment of Neurological and Psychiatric Disorders.

摘要

Claim 1: A compound having the formula (1) or a stereochemically isomeric form thereof, wherein the bond drawn into the ring indicates that the bond can be attached to any atom of the carbon ring; R1 is selected from the group consisting of hydrogen; C1-6 alkyl, (C1-3 alkyloxy) C1-3 alkyl, [(C1-3 alkyloxy) -C1-3alkyloxy] C1-3 alkyl; C1-3 alkyl substituted with one or more independently selected halo substituents; unsubstituted benzyl; benzyl substituted with one or more substituents each independently selected from the group consisting of halo, C1-3 alkyl, C1-3 alkyloxy C1-3 alkyl, C1-3 alkyloxy, C1-3 hydroxyalkyl, cyano,Hydroxy, amino, C (= O) r ',it is life.C (3DO) NR Rmono- or di- (C1-3 alkyl) amino, morpholinyl, (C3-7 cycloalkyl) C1-3 alkyloxy, trifluoromethyl and trifluoromethoxy, where R 'and Rö are independently selected from hydrogen and C1-6 alkyl, (benzyloxy) alkyl C1-3; unsubstituted C3-7 cycloalkyl; C3-7 cycloalkyl substituted with one or more independently selected C1-3 alkyl substituted with one or more independently selected halo substituents; (C3-7 cycloalkyl) C1-3 alkyl; 4- (2,3,4,5-tetrahydro-benzo [f] [1,4] oxazepin) methyl; Het1; Het1 C1-3alkyl, Het2 and Het2 C1-3alkyl; R2 is selected from the group consisting of cyano; halo; C1-3 alkyl substituted with one or more independently selected halo substituents;C1-3 tar is replaced by one or more independently selected halogen substitutes; c1-3 tar; c3-7 cyclopentadiene; c1-3 tar (cyclopentadiene c3-7); a-d-forms a radical form in (a),(b)(c)(d) And (E);The links drawn in (a) indicate that R4 can be connected to any atom in carbon rings 2 and 3; each R3 should be independent of the hydrogen group; C1-6 is not replaced; C1-6 is replaced by one or more substitutes, independent of the halogen group, Hydrogen Xi, alcoxi c1-3 and trifluoromethane; unsubstituted cyclopentanediol c3-7; unsubstituted cyclopentanediol c3-7; cyclopentanediol c3-7 substituted by one or more substitutes, independent of halogen, c1-3 hydrocarbon, hydroxyl, c1-3 and trifluoromethane groups; cyclopentanediol c3-7-c1-3 tar; unsubstituted phenyl;One or more alternatives are used to replace phenyl, independent of the substances of halogen, c1-3 tar, c1oxy c1-3 and trifluoromethyl, hett3 and hett3 tar c1-3 groups, or R8 is selected from c1-3 tar respectively from a cyclic equation excimer (f), C1-3 hydrocarbon and c1-3 hydroxyhydrazide; q is 1 or 2; X is selected from O, CH2 and CR9 (OH).R9 is selected from hydrogen, c1-3 hydrocarbon and cyclo-7; or X is a periodic equation radical (g), where R and s are independently selected between 0, 1 and 2, provided that R + S = 2; per R4, R6 and R7 are independently selected from c1-3 and c1-3 tar replaced by one or more independently selected halogenated substitutes; each R5 is a group of hydrogen, c1-3 tar and c1-3 tar replaced by one or more independently selected halogenated substitutes; N, M While P is selected from 0, 1 and 2 respectively; V equals 0 or 1;T and u are independently selected from 1 and 2, W from N and CR10, R10 from hydrogen, halogen and methyl trifluoride, and each het1 is a saturated heterocyclic radical selected from pyridine, pyridyldi, pyridyldi, pyridine and morphine, each of which can be replaced by one or more alternatives. Plus each individual C1-6 tar group, monkey group,Di-y tri halogequile c1-3; unsubstituted phenyl; and phenyl substituted by 1, 2 or 3 substitutes independently selected from the halogenated, trifluoromethyl, and trifluoromethyl compound groups; each het2 is pyridine or pyridine; each het3 is a different heterocycle selected from the tetrahydropyridine, pyridan, and pyridinediol groups. Choose to replace each selected alternative with one or more alternatives, regardless of the categories consisting of halogen, c1-3 tar, alcoxi c1-3 and trifluoromethyl; and choose halogen from fluorine, chlorine, bromine and iodine or from salt or solution acceptable to the same agent.