2 - oxo - Derivatives of alkyl piperazin - 1 - 2 - ona, their preparation, Pharmaceutical composition that comprises and their use in the treatment of diseases mediated by receptor p75NTR.

摘要

From 4 - {2 - [phenyl-3,6-dihydro-pyridine-1-il] - 2-oxo-tar} - 1-pyridine-2-ona and 4 - {2 - [phenyl-2,5-dihydro-pyridine-1-il] - 2-oxo-tar} - 1-pyridine-2-ona. It is prepared and applied by therapists in the treatment of diseases transmitted by p75NTR receivers. The forum where you want to post is a 1. Requirement 1: it consists of formula (1), where M represents 0 or 1; a represents formula (2) and B represents a hydrogen or a represents a hydrogen, and B represents formula (2);R1 and R2, different or different characteristics, respectively, represent a hydrogen or halogen compound, a group of C1-4, C1-4, perfluorooctylsulfonyl, C1-2, alcox C1-4 or a group of trifluoroenzymes; n is 1 or 2; R3 represents a group of e formula (3), wherein R4 and R5, different or different characteristics, are in any available position, They independently represent a hydrogen or halide, a hydroxy, a C1-4 tar group, a C1-2 perfluoroalkyl, a C1-4 perfluorooctylsulfonyl, a c1oxy C1-4, a trifluoroectane sulfonic acid, a cyanogen, a COOH, cookie, CONH2, conr6r7, or NHRC group; R, R6, and R7 represent a C1-6 tar; present in the form of a base or an acid salt.