oligonucleotide, method for inducing apoptosis of neoplastic cells of cell b, method for increasing cd40 expression in neoplastic cells of b cell, method for inducing neoplastic cells of b cell to produce il - 10, pharmaceutical composition and use of an oligonucleotide

摘要

Oligonucleotide, method for inducing apoptosis of neoplastic cell And, method for increasing the expression of CD40 in cell malignant cell B CELLS method for inducing neoplastic B-cell to produce IL-10 Pharmaceutical Composition and Use an oligonucleotide. The invention provides nine oligonucleotides having sequences of SEQ ID NO: 1-9 or their functional homologues or a composition comprising them and a method for treating B cell neoplasia using the oligonucleotides or their functional homologues or the composition comprising the oligonucleotides. Oligonucleotides induce apoptosis of B-cell neoplastic cells, up-regulate CD40 in B-cell neoplastic cells, and stimulate IL-10 production from B-cell neoplastic cells.