method of inhibiting class d enzymes in the treatment of bacterial infection in a patient in need

摘要

This invention relates to certain bicyclic 6-alkylidene penems acting as inhibitors of class-D enzymes. 225 -lactamases hydrolyze 225 -lactam antibiotics and as such serve as a primary cause of bacterial resistance. The compounds of the present invention when combined with? -Lactam antibiotics will provide effective treatment against life-threatening bacterial infections. In accordance with the present invention, compounds of formula 1 or a pharmaceutically acceptable salt or in vivo hydrolysable R5 ester thereof are provided: Formula (1) wherein: one of A and B denotes hydrogen and the other a fused bicyclic heteroaryl group optionally substituted; and X = O or S.