Method for inhibiting the Enzyme beta lactamase Class D in the treatment of bacterial infection in a patient

摘要

Penemes alkylidene 6 Tricyclic inhibitors of Enzymes with activity as a class D beta lactamase hydrolyse beta lactam Antibiotics, and as such serve as the primary cause of Bacterial Resistance when combined with beta lactam Antibiotics, the compounds of This provided an effective treatment against bacterial infections that threaten Life.Provided are compounds of formula (1) are useful for the treatment of bacterial infections that are associated with this Enzyme Class D: One, where a and B denote Hydrogen and optionally substituted heteroaryl FUSED tricyclic Group; and X is s or or.Claim 1: a method to inhibit Enzymes of Class D in the treatment of Class D to inhibit enzymes in the treatment of bacterial infection in a patient in need thereof, characterized by understanding provide an effective amount of a compound of formula (1),Where: one of a and B denote Hydrogen and the other a tricyclic FUSED heteroaryl Group optionally substituted; X is s or R5 is H, alkyl or cycloalkyl C1 - C5 - 6, 6 -, and alquiloc1 6chr30co; R3 is Hydrogen, alkyl C1 - C5 - 6 6, cycloalkyl, optionally substituted aryl or heteroaryl optional Mind replaced; or a pharmaceutically acceptable Salt or Ester is hydrolyzed in vivo.