首页> 外国专利> System and Method for determining Individualized medical intervention to a disease State

System and Method for determining Individualized medical intervention to a disease State

机译:确定针对疾病状态的个性化医疗干预措施的系统和方法

摘要

1. - determine the method of medical intervention for disease condition, including the following steps: - do at least one thing between gene detection and protein detection of gene expression extracted from biological samples of patients: - determine what factors and / or proteins are in gene expression gene and / or protein 1. Changes in terms and ways of reference;E-determine drug treatment methods for interacting with proteins expressed in at least one gene and / or gene, and the expression mode of these genes changes, not limited to one disease. 2. - the method required in Item 1, in which a drug treatment method for interaction with at least one gene and / orProteins that show changes in genes include changes in the determination of drug treatment methods from data generated from at least one comprehensive literature database and clinical trials that are automatically revised. 3. Method of claim 1, i.e. to accomplish at least one thing between the tests of the IPCCN and an expressed gene protein test include at least one immunochemical analysis (IHC) and one micro screening analysis (4). The third method, in which the steps of micro screening analysis include analysis by at least one micro screening method. Common terms and phrasesA microparticle genomic hybrid method (CGH)A micromorphological selective mononucleoside (SNP)1. Fluorescence field fig,in-situ hybridization (ISH) and proteomic selection. 5. The method of Claim 3 wherein the step of performing an IHC analysis comprises the step of performing an IHC analysis for a expressed protein of a gene that includes at least one of the following: Her2 / Neu, ER, PR, c -kit, EGFR, MLH1, MSH2, CD20, p53, cyclin D1, bcl2, COX-2, androgen receptor, CD52, PDGFR, AR, CD25 and VEGF.
机译:1.-确定针对疾病状况的医学干预方法,包括以下步骤:-在从患者生物样本中提取的基因表达的基因检测和蛋白质检测之间进行至少一件事:-确定其中存在哪些因素和/或蛋白质基因表达基因和/或蛋白质1.术语和参考方式的变化; E-决定与至少一种基因和/或基因表达的蛋白质相互作用的药物治疗方法,并且这些基因的表达方式改变,但不限于一种疾病。 2.-第1项中要求的方法,其中与至少一种基因和/或显示基因变化的蛋白质相互作用的药物治疗方法包括根据从至少一个综合文献数据库生成的数据确定药物治疗方法的变化和自动修订的临床试验。 3.根据权利要求1所述的方法,即,要完成所述IPCCN的测试与表达的基因蛋白质测试之间的至少一项,包括至少一项免疫化学分析(IHC)和一项微量筛选分析(4)。第三种方法,其中微筛选分析的步骤包括通过至少一种微筛选方法进行的分析。常用术语和短语微粒基因组杂交法(CGH)一种微形态选择性单核苷(SNP)1。荧光场无花果,原位杂交(ISH)和蛋白质组学选择。 5.权利要求3的方法,其中进行IHC分析的步骤包括对包括以下至少之一的基因的表达蛋白进行IHC分析的步骤:Her2 / Neu,ER,PR,c-kit ,EGFR,MLH1,MSH2,CD20,p53,细胞周期蛋白D1,bcl2,COX-2,雄激素受体,CD52,PDGFR,AR,CD25和VEGF。

著录项

  • 公开/公告号CO6141496A2

    专利类型

  • 公开/公告日2010-03-19

    原文格式PDF

  • 申请/专利权人 MOLECULAR PROFILING INSTITUTE INC;

    申请/专利号CO20080122494

  • 发明设计人 VAN HOFF DANIEL;PENNY ROBERT;

    申请日2008-11-18

  • 分类号G06F19;

  • 国家 CO

  • 入库时间 2022-08-21 18:47:12

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号