首页> 外国专利> General-purpose composition for enhancing stamina, prevention, prophylaxis and therapy of Lyme borreliosis for human and veterinary application, process for preparing such composition and its use

General-purpose composition for enhancing stamina, prevention, prophylaxis and therapy of Lyme borreliosis for human and veterinary application, process for preparing such composition and its use

机译:用于人和兽用的增强耐力,预防,预防和治疗莱姆病的耐力的通用组合物,制备该组合物的方法及其用途

摘要

Universal preparation to enhance immunity, prevention, prophylaxis and treatment of Lyme disease for human and veterinary use, formed based on whole-cell bacterins or bacterial lysates or bacterial purifikátu in liquid form or as a lyophilisate least one or more genomospecies pathogenic Borrelia, wherein each of genomospecies Borrelia, selected preferably from the group of Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii, contains both at least one immunogenic protective protein of outer membrane, either OspA or OspC, or simultaneously both the immunogenic protective proteins OspA and OspC, eventually possibly other immunogenic protective proteins of outer membrane, and secondly, the whole-cell bacterins or bacterial lysates or purified bacterial in liquid or lyophilized form of the selected immunomodulating Propionibacterium acnes strain or other bacterial strain immunomodulatory. The preparation can be administered by intramuscular, subcutaneous, intradermal, transkutáne, prospecting or orally to induce active protective immunity to natural infection through infected ticks common to all three nejpatogenejšími genome species of Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii and because of the principle of cross-immunity or even to other known genome species of borrelia.
机译:通用制剂,用于增强人和兽用莱姆病的免疫力,预防,预防和治疗,其以液体或作为一种或多种至少一种或多种基因组病原性致病性疏螺旋体的冻干物的全细胞细菌或细菌裂解物或细菌纯化物的形式形成,其中每种最好选自Borrelia burgdorferi sensu stricto,Borrelia afzelii和Borrelia garinii的基因型博雷利亚氏菌包含外膜的至少一种免疫原性保护蛋白,即OspA或OspC,或同时包含免疫原性保护性蛋白OspA和OspC,最终可能是外膜的其他免疫原性保护蛋白,其次是选定的免疫调节痤疮丙酸丙酸杆菌菌株或其他细菌调节剂的液体或冻干形式的全细胞细菌素或细菌裂解物或纯化的细菌。可以通过肌肉内,皮下,皮内,transkutáne,前瞻性或口服施用该制剂,以通过对伯氏疏螺旋体,疏氏疏螺旋体和百日咳疏螺旋体的所有三种nejpatogenejšími基因组种共有的感染tick来诱导对自然感染的主动保护性免疫。交叉免疫或什至与其他已知的疏螺旋体基因组种的原理。

著录项

  • 公开/公告号CZ2008501A3

    专利类型

  • 公开/公告日2010-03-03

    原文格式PDF

  • 申请/专利权人 BITTNER LIBOR;VRZAL VLADIMIR;

    申请/专利号CZ20010020085

  • 发明设计人 BITTNER LIBOR;VRZAL VLADIMIR;

    申请日2008-08-20

  • 分类号A61K39/02;A61K39/05;A61K39/116;A61P31/04;C12N1/20;C12N1/36;

  • 国家 CZ

  • 入库时间 2022-08-21 18:47:13

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