USE OF SERUM-FREE CULTURE MEDIUM COMPRISING AN ANTIOXIDANT FOR REDUCING LEVELS OF OXIDIZED FORMS OF RECOMBINANT DIMERIC GONADOTROPIN

摘要

The present invention is in the field of the manufacture of recombinant proteins. More specifically, it relates to the use of a serum-free culture medium comprising an antioxidant for the production of recombinant dimeric gonadotropins. The antioxidant may be selected from the group consisting of L-glutathione, 2-mercaptoethanol, L- methionine and a combination of ascorbic acid and of (+)-alpha-tocopherol.