HUMAN MONOCLONAL ANTIBODIES TO CD89, ANTIGEN BINDING PORTIONS THEREOF, HYBRIDOMAS AND TRANSFECTOMAS PRODUCING THEM, TRANSGENIC CELLS EXPRESSING THEM, BISPECIFIC, MULTISPECIFIC, MOLECULE CONJUGATES, IMMUNOTOXINS AND COMPOSITIONS COMPRISING THEM, METHODS OF PRODUCTION THEREOF AND METHODS OF DETECTION THEREOF

摘要

Human monoclonal antibodies which bind specifically to Fc alpha receptor (CD89), including monoclonal antibodies which react specifically to Fc receptor for IgA of human effector cells are disclosed. The binding agents, e.g., antibodies are useful for targeting human effector cells (e.g. macrophages) against a target cell (e.g. a cancer cell, an infectious agent, etc.). For this purpose, bifunctional antibodies or heteroantibodies can be constructed containing the binding region derived from an anti-Fc-alpha receptor antibody and the binding region of a target-specific antibody. Targeted effector cells can specifically lyse target cells.