7,9-SUBSTITUTED TETRACYCLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND COMMERCIAL PACKAGES COMPRISING SAID COMPOUNDS AND USE OF SAID COMPOUNDS IN THE PREPARATION OF A MEDICAMENT FOR TREATING A TETRACYCLINE RESPONSIVE STATE

摘要

The present invention pertains to novel 7,9-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.