STORAGE STABLE PHARMACEUITCAL PREPARATION CONTAINING OXYCODONE AND NALOXONE WITH SUSTAINED, INVARIANT AND INDEPENDENT RELEASE

摘要

The invention concerns a storage stable pharmaceutical formulation comprising preferably two active compounds in a non-swellable diffusion matrix, whereby the compounds are released from the matrix in a sustained, invariant and, if several compounds are present, independent manner and the matrix is determined with respect to its substantial release characteristics by ethylcellulose and at least one fatty alcohol. The invention also concerns methods for producing such pharmaceutical formulations.