SYNTHESIS OF PHENYL NITRATE DERIVATIVES OF FREE CARBOXYLIC ACID GROUP CONTAINING NSAIDS AS CYCLOOXYGENZISE INHIBITOR FOR ANTI-FLAMMATORY, ANALGESIC AND SMOOTH MUSCLE RELAXANT ACTIVITY

摘要

The present invention describes the synthesis of phenyl nitrate derivatives of free carboxylic acid group containing NSAIDs as cyclooxygenase inhibitor and nitric oxide donors (CINOD) for anti-inflammatory, analgesic and smooth muscle relaxant activity, novel cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions comprising at least one cyclooxygenase 2 (COX-2) inhibitor, and, at least one compound that donates, transfers, releases nitric oxide and/or stimulates endogenous synthesis of nitric oxide and/or elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.