首页> 外国专利> '4-(6-FLUORO-7-METHYLAMINO-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL -5-CHLORO-THIOPHEN-2-YL-SULFONYLUREA SALTS, IN DIFFERENT CRYSTALLINE FORMS, PHARMACEUTICAL COMPOSITIONS THEREOF'

'4-(6-FLUORO-7-METHYLAMINO-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL -5-CHLORO-THIOPHEN-2-YL-SULFONYLUREA SALTS, IN DIFFERENT CRYSTALLINE FORMS, PHARMACEUTICAL COMPOSITIONS THEREOF'

机译:“ [[4-(6-氟代-7-甲基氨基-2,4-二氧杂-1,4-二氢-2H-喹唑啉-3-基)-苯基] -5-氯-噻吩-2-基-磺基脲盐,在不同的晶体形式中,其药物成分”

摘要

The present invention provides novel sulfonylurea salts of a salt of formula (I) and polymorph forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a salt of formula (I) or a pharmaceutically acceptable form thereof.
机译:本发明提供了式(I)的盐的新型磺酰脲盐及其多晶型物形式。各种形式的化合物是有效的血小板ADP受体抑制剂,可用于各种药物组合物中,对预防和/或治疗心血管疾病,特别是与血栓形成有关的疾病特别有效。本发明还提供了在哺乳动物中制备此类化合物和形式以及预防或治疗血栓形成和与血栓形成相关的病症的方法,该方法包括给予治疗有效量的式(I)的盐或其药学上可接受的形式的步骤。

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