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METHODS AND COMPOSITIONS CAPABLE OF CAUSING POST-TRANSCRIPTIONAL SILENCING OF GENE EXPRESSION IN A SYNERGIC MANNER.
METHODS AND COMPOSITIONS CAPABLE OF CAUSING POST-TRANSCRIPTIONAL SILENCING OF GENE EXPRESSION IN A SYNERGIC MANNER.
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机译:能够以协同方式引起基因表达的转录后沉默的方法和组合物。
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摘要
The invention relates to compositions intended for post-transcriptional inhibition of gene expression through the combined use of: a modified U1 RNA directed against a pre-selected region in a target pre-mRNA-, and a siRNA-, shRNA and/or miRNA-type gene expression silencing agent, as well as to the use of said combinations for the treatment of diseases caused by the unwanted overexpression of a protein.
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