Derivatives of N-phenyl(pyrrolidine-2-yl)methylbenzamide and N-(azepan-2-yl)phenylmethylbenzamide, preparation method thereof and application of same in therapeutics

摘要

Disclosed is a compound corresponding to the general formula (I) in which n represents the number 1 or 3, R1 represents either a hydrogen atom, a linear or branched (C1 -C7)alkyl group optionally substituted with one or more fluorine atoms, a (C3-C7)cycloalkyl group, a (C3 C7) cycloalkyl (C1 -C3) alkyl group, a phenyl(C1 -C3)alkyl group optionally substituted with one or two methoxy groups, a (C2-C4) alkenyl group, or a (C2 -C4) alkynyl group, X represents either a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl and linear or branched (C1 -C6) alkyl and (C1 -C6) alkoxy groups, R2 represents either a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, linear or branched (C1 -C6) alkyl and (C1 -C6) alkoxy, (C3-C7) cycloalkyl, phenyl, cyano, acetyl, benzoyl, S (C1 -C6) alkyl, (C1 -C6) alkylsulfonyl, carboxyl and (C1 -C6) alkoxycarbonyl groups, or a group of general formula NR3R4, SO2NR3R4 or CONR3R4, in which R3 and R4 represent, independently of each other, a hydrogen atom or a linear or branched (C1 -C6)alkyl or (C3-C7) cycloalkyl group, or form, with the nitrogen atom that bears them, a pyrrolidine, piperidine or morpholine ring, in the form of base or of acid-addition salt. Also disclosed is the use if the above compound of formula (I) in the preparation of the medicament for the treating of behavioural disorders associated with dementia, psychosis, various forms of anxiety, panic attacks, phobia, compulsive obsessive disorders, various forms of depression, disorders caused by alcohol abuse or weaning from alcohol, sexual behaviour disorders, eating disorders and migraine, contracture, pain, Parkinson's disease and Parkinson like symptoms, epilepsy, mixed forms epileptic syndromes in addition to antiepileptic treatment, or in monotherapy, apnea, and for neuroprotection.