Use of inositol hexaphosphate or inositol hexasulphate to complex biologically active compounds for the preparation of controlled release pharmaceutical compositions

摘要

Disclosed is a pharmaceutical composition which comprises: a) a complex of a biologically active compound having at least one basic functional group and a polyanion that is inositol hexaphosphate or inositol hexasulphate; and b) a pharmaceutically acceptable carrier comprising a biodegradable, water-insoluble polymer. Also disclosed is the use of the above pharmaceutical composition in the manufacture of a sustained, controlled release medicament for treating warm-blooded animals in need of such treatment. Additionally, a process for the preparation of the above composition is also disclosed, comprising: a) separately dissolving a biologically active compound having at least one basic functional group, and a polyanion that is inositol hexaphosphate or inositol hexasulphate; and b) mixing the dissolved biologically active compound and polyanion to produce a complex; and c) dispersing the complex into a pharmaceutically acceptable carrier comprising a biodegradable, water-insoluble polymer.