MODIFIED HUMAN MANGANESE SUPEROXIDE DISMUTASE AND USES THEROF

摘要

The present invention refers to a novel modified form of hMnSOD that can be produced and secreted from cells of human liposarcoma in continuous culture. This protein is obtainable :by ionic exchange chromatography, gel filtration and immunoaffinity techniques from the culture medium in which these cells release it. Moreover the present invention refers to the use of this modified hMnS.OD for preparation of a medicament for prevention and therapy of tumors, of septic and traumatic shock, diabetic neuropathy, post-herpetic neuritis and malignant hyperthermia and for healing of cutaneous lesions.