ANTIBODIES WITH T-CELL-RECEPTOR-SPECIFIC SPECIFICITY, BUT HIGHER AFFINITY AND ITS USE FOR THE DETECTION AND TREATMENT OF CANCER, VIRUS INFECTIONS AND AUTOIMMUNE DISEASES

摘要

An isolated molecule which comprises an antibody specifically bindable with a binding affinity below 20 nanomolar, preferably below 10 nanomolar, to a human major histocompatibility complex (MHC) class I being complexed with a HLA-restricted antigen and optionally further comprises an identifiable or therapeutic moiety conjugated to the antibody.