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WARFARIN SENSITIVITY PREDICTIVE GENETIC VARIANTS OF VKORC1
WARFARIN SENSITIVITY PREDICTIVE GENETIC VARIANTS OF VKORC1
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机译:VKORC1的华法林敏感性预测遗传变异
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摘要
We discovered that a polymorphism in the promoter of the VKORCI gene is associated with warfarin sensitivity. This polymorphism can explain both the interindividual and inter-ethnic differences in warfarin dose requirements. Furthermore, the polymorphism is also associated with promoter activity. Thus, the promoter sequence or activity of the VKORCI gene of a subject can be used to predict how much warfarin should be prescribed for the subject. Relevant methods and compositions are provided.
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