animal model of Alzheimer's disease, procedure and applications obtencion disease.

摘要

animal model of Alzheimer's disease, preparation process and applications.; The transgenic non-human animal as non-human animal model for studying Alzheimer's disease (AD) is characterized in that contains in its genome, a heterologous polynucleotide (transgene) comprising the nucleotide sequence of the complete human APP gene together with the regulatory sequences, and has an endogenous expression pattern similar to the endogenous expression pattern of the hAPP gene in humans. Application in the study AD and in the screening of potentially useful for the prevention and / or treatment of AD compounds.