NON-RACEMIC BLENDS OF (R) -N-PIPERIDINIL-5- (4-CHLOROPHENYL) -1- (2,4-DICLOROPHENYL) -4,5-DIHYDRO-1H-PIRAZOL-3-CARBOXAMIDE AND (S) -N- PIPERIDINIL-5- (4-CHLOROPHENYL) -1- (2,4-DICLOROPHENIL) -4,5-DIHIDRO-1H-PIRAZOL-3-CARBOXAMIDA

摘要

The present invention relates to non-racemic mixtures of (R)-N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide and (S)-N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydro-1 H-pyrazole-3-carboxamide, methods for their preparation, medicaments comprising the mixtures as well as use for the preparation of a medicament for the treatment of humans and animals and the use of (S)-N-piperidinyl-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4,5-dihydro-1H-pyrazole-3-carboxamide in the prophylaxis and/or treatment of dyslipidaemia and other metabolic disturbances that result from the excessive consumption of highly palatable macronutrient food sources.