PROCESS OF OBTAINING AND BIOMEDICAL APPLICATIONS OF ALTERNATE POLYESTERS CONSTITUTED BY UNITS OF GLYCOLIC ACID AND ALIFATIC HYDROXIACIDES.

摘要

Obtaining process and biomedical applicationsof alternating polyesters consisting of acid unitsglycolic and aliphatic hydroxy acids.;The invention refers to a new processof synthesis that is suitable for the preparation of copolyesterswith an alternating sequence and that are constituted by unitsof glycolic acid and various hydroxy acids of naturealiphatic;The hydroxy acids can be linear orpresent lateral methyl groups, as is the case with acid3-hydroxybutyric.;All polymers can be described by thegeneric formula:; vskip1.000000 baselineskip ;- [O (CH 2) COOCHR (CH 2) n-2 CO] x -;where n varies from 3 to 10 and Rit can be a hydrogen atom or a groupmethyl.;Some of these materials can be used inthe biomedical sector as drug releasing systems, beingderivatives of glycolic acids,3-hydroxybutyric and6-hydroxyhexanoic especially interesting.;The degradability of thematerials, their biocompatibility and their solubility in solventsvolatile organic that allows its preparation in the form ofmicrospheres in which the required drug is included.