Process of obtaining and biomedical applications of alternating polyesters constituted by units of glycolic acid and aliphatic hydroxyiaids (Machine-translation by Google Translate, not legally binding)

摘要

Obtaining process and biomedical applications of alternating polyesters constituted by units of glycolic acid and aliphatic hydroxy acids. The invention relates to a new synthesis process that is suitable for the preparation of copolyesters with an alternating sequence and which are constituted by glycolic acid units and different hydroxy acids of aliphatic nature. The hydroxy acids can be linear or have side methyl groups, as is the case with 3-hydroxybutyric acid. All polymers can be described by the generic formula: Co 2 co 2 co 2 Where n ranges from 3 to 10 and r can be a hydrogen atom or a methyl group. Some of these materials can be used in the biomedical sector as drug-releasing systems, being the glycolic, 3-hydroxybutyric and 6-hydroxyhexanoic acid derivatives especially interesting. Key points are the degradability of the materials, their biocompatibility and their solubility in volatile organic solvents that allows their preparation in the form of microspheres in which the required drug is included. (Machine-translation by Google Translate, not legally binding)